Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published August 16, 2007 | Supplemental Material
Journal Article Open

Contributions of the Amygdala to Reward Expectancy and Choice Signals in Human Prefrontal Cortex


The prefrontal cortex (PFC) receives substantial anatomical input from the amygdala, and these two structures have long been implicated in reward-related learning and decision making. Yet little is known about how these regions interact, especially in humans. We investigated the contribution of the amygdala to reward-related signals in PFC by scanning two rare subjects with focal bilateral amygdala lesions using fMRI. The subjects performed a reversal learning task in which they first had to learn which of two choices was the more rewarding, and then flexibly switch their choices when contingencies changed. Compared with healthy controls, both amygdala lesion subjects showed a profound change in ventromedial prefrontal cortex (vmPFC) activity associated with reward expectation and behavioral choice. These findings support a critical role for the human amygdala in establishing expected reward representations in PFC, which in turn may be used to guide behavioral choice.

Additional Information

© 2007 Elsevier Inc. Received 2 March 2007, Revised 14 June 2007, Accepted 16 July 2007, Available online 15 August 2007Published: August 15, 2007. This work was supported by a grant from the Gordon and Betty Moore Foundation (to J.O.D. and R.A.), the National Institutes of Health (to R.A.), and the Gimble Discovery Fund for Neuroscience (J.O.D).

Attached Files

Supplemental Material - mmc1.pdf


Files (864.3 kB)
Name Size Download all
864.3 kB Preview Download

Additional details

August 22, 2023
October 24, 2023