Published March 2016
| public
Conference Paper
Non-canonical amino acids as tools for protein medicinal chemistry
- Creators
- Tirrell, David
- Fang, Katherine
- Lieblich, Seth
Abstract
The engineering of therapeutic proteins has been advanced enormously by methods for site-directed mutagenesis. This lecture will describe an alternative, complementary approach, in which non- canonical amino acids are used to engineer protein-protein interactions, protein solvation and chain trajectory, with the objective of controlling the stability and pharmacokinetics of protein therapeutics.
Additional Information
© 2016 American Chemical Society.Additional details
- Eprint ID
- 65790
- Resolver ID
- CaltechAUTHORS:20160331-090004894
- Created
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2016-03-31Created from EPrint's datestamp field
- Updated
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2019-10-03Created from EPrint's last_modified field