CaltechAUTHORS
Published September 1, 2014 | Version public
Journal Article Metadata-only

MicroRNA-125b Represses IRF4 to Induce Acute Myeloid Leukemia

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Abstract

MicroRNA-125b (miR-125b) is upregulated in a variety of neoplastic blood disorders. We previously showed that miR-125b expression is enriched in hematopoietic stem and progenitor cells (HSPCs), and that upregulation of miR-125b in the mouse hematopoietic system causes an aggressive acute myeloid leukemia. Here we elucidate the molecular mechanism by which miR-125b causes acute myeloid leukemia.

Additional Information

© 2014 Published by Elsevier Inc. Author Disclosure: A. Chaudhuri: None. A.Y. So: None. R. Sookram: None. D. Baltimore: K. Advisory Board; Regulus Therapeutics.

Additional details

Identifiers

Eprint ID
50774
DOI
10.1016/j.ijrobp.2014.05.2230
Resolver ID
CaltechAUTHORS:20141024-094315621

Related works

Describes
10.1016/j.ijrobp.2014.05.2230 (DOI)

Dates

Created
2014-10-24
Created from EPrint's datestamp field
Updated
2021-11-10
Created from EPrint's last_modified field