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Published March 12, 2009 | Supplemental Material + Accepted Version
Journal Article Open

Lesion mapping of cognitive abilities linked to intelligence


The Wechsler Adult Intelligence Scale (WAIS) assesses a wide range of cognitive abilities and impairments. Factor analyses have documented four underlying indices that jointly comprise intelligence as assessed with the WAIS: verbal comprehension (VCI), perceptual organization (POI), working memory (WMI), and processing speed (PSI). We used nonparametric voxel-based lesion-symptom mapping in 241 patients with focal brain damage to investigate their neural underpinnings. Statistically significant lesion-deficit relationships were found in left inferior frontal cortex for VCI, in left frontal and parietal cortex for WMI, and in right parietal cortex for POI. There was no reliable single localization for PSI. Statistical power maps and cross-validation analyses quantified specificity and sensitivity of the index scores in predicting lesion locations. Our findings provide comprehensive lesion maps of intelligence factors, and make specific recommendations for interpretation and application of the WAIS to the study of intelligence in health and disease.

Additional Information

© 2009 Elsevier B.V. Accepted 29 January 2009. Published: March 11, 2009. Available online 11 March 2009. This work was supported in part by the Akademie der Naturforscher Leopoldina LPD Grant 9901/8-140 (J.G.); by grants from the National Institutes of Health: R01 NS054266 (C.R.), P01 NS19632 (D.T., H.D., and R.A.), and R01 DA022549 (D.T.); and by the Gordon and Betty Moore Foundation (R.A.). The authors declare no conflict of interest.

Attached Files

Accepted Version - nihms102717.pdf

Supplemental Material - Glascher2009p1225Neuronsupp.pdf


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