CaltechAUTHORS
Published May 2022 | Version Published
Journal Article Open

Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium

Creators

  • 1. ROR icon Northwestern University
  • 2. ROR icon Brigham and Women's Hospital
  • 3. ROR icon Harvard University
  • 4. ROR icon University of Chicago
  • 5. ROR icon University of Pittsburgh
  • 6. ROR icon Washington University in St. Louis
  • 7. ROR icon University of Southern California
  • 8. ROR icon University of Washington
  • 9. ROR icon University of Arizona
  • 10. ROR icon Vanderbilt University Medical Center
  • 11. ROR icon Mount Desert Island Biological Laboratory

Abstract

Acute kidney injury impacts ∼13.3 million individuals and causes ∼1.7 million deaths per year globally. Numerous injury pathways contribute to acute kidney injury, including cell cycle arrest, senescence, inflammation, mitochondrial dysfunction, and endothelial injury and dysfunction, and can lead to chronic inflammation and fibrosis. However, factors enabling productive repair versus nonproductive, persistent injury states remain less understood. The (Re)Building a Kidney (RBK) consortium is a National Institute of Diabetes and Digestive and Kidney Diseases consortium focused on both endogenous kidney repair mechanisms and the generation of new kidney tissue. This short review provides an update on RBK studies of endogenous nephron repair, addressing the following questions: (i) What is productive nephron repair? (ii) What are the cellular sources and drivers of repair? and (iii) How do RBK studies promote development of therapeutics? Also, we provide a guide to RBK’s open access data hub for accessing, downloading, and further analyzing data sets.

Copyright and License

© 2022, International Society of Nephrology. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Funding

The authors acknowledge support from the National Institute of Diabetes and Digestive and Kidney Diseases (Re)Building a Kidney (RBK) consortium cooperative agreements DK126038 (JVB), DK108215 (JAH), DK126122 (NAH), DK126024 (BDH), DK107350 (CK), DK126024 (APM), DK126006 (SJS), BX002660 (JAW), DK126122 (MPdC), DK126021 (IAD), F30DK123985, and T32GM008152 support (BAN).

Acknowledgement

We also acknowledge the RBK Consortium Monitoring Board for their input: Dale Abrahamson (University of Kansas Medical Center), Dennis Brown (Massachusetts General Hospital), Alison Kohan (University of Pittsburgh), Thomas Peterson (United Therapeutics), William Welch (Georgetown University), and Kaiming Ye (State University of New York).

Files

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Additional details

Funding

National Institute of Diabetes and Digestive and Kidney Diseases
DK126038
National Institute of Diabetes and Digestive and Kidney Diseases
DK108215
National Institute of Diabetes and Digestive and Kidney Diseases
DK126122
National Institute of Diabetes and Digestive and Kidney Diseases
DK126024
National Institute of Diabetes and Digestive and Kidney Diseases
DK107350
National Institute of Diabetes and Digestive and Kidney Diseases
DK126006
National Institute of Diabetes and Digestive and Kidney Diseases
BX002660
National Institute of Diabetes and Digestive and Kidney Diseases
DK126021
National Institute of Diabetes and Digestive and Kidney Diseases
F30DK123985
National Institute of Diabetes and Digestive and Kidney Diseases
T32GM008152

Dates

Accepted
2022-02-16
Accepted
Available
2022-03-09
Published online
Available
2022-04-20
Version of record

Caltech Custom Metadata

Caltech groups
Division of Biology and Biological Engineering (BBE)
Publication Status
Published