Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium
-
1.
Northwestern University
-
2.
Brigham and Women's Hospital
-
3.
Harvard University
-
4.
University of Chicago
-
5.
University of Pittsburgh
-
6.
Washington University in St. Louis
-
7.
University of Southern California
-
8.
University of Washington
-
9.
University of Arizona
-
10.
Vanderbilt University Medical Center
-
11.
Mount Desert Island Biological Laboratory
Abstract
Acute kidney injury impacts ∼13.3 million individuals and causes ∼1.7 million deaths per year globally. Numerous injury pathways contribute to acute kidney injury, including cell cycle arrest, senescence, inflammation, mitochondrial dysfunction, and endothelial injury and dysfunction, and can lead to chronic inflammation and fibrosis. However, factors enabling productive repair versus nonproductive, persistent injury states remain less understood. The (Re)Building a Kidney (RBK) consortium is a National Institute of Diabetes and Digestive and Kidney Diseases consortium focused on both endogenous kidney repair mechanisms and the generation of new kidney tissue. This short review provides an update on RBK studies of endogenous nephron repair, addressing the following questions: (i) What is productive nephron repair? (ii) What are the cellular sources and drivers of repair? and (iii) How do RBK studies promote development of therapeutics? Also, we provide a guide to RBK’s open access data hub for accessing, downloading, and further analyzing data sets.
Copyright and License
© 2022, International Society of Nephrology. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Funding
The authors acknowledge support from the National Institute of Diabetes and Digestive and Kidney Diseases (Re)Building a Kidney (RBK) consortium cooperative agreements DK126038 (JVB), DK108215 (JAH), DK126122 (NAH), DK126024 (BDH), DK107350 (CK), DK126024 (APM), DK126006 (SJS), BX002660 (JAW), DK126122 (MPdC), DK126021 (IAD), F30DK123985, and T32GM008152 support (BAN).
Acknowledgement
We also acknowledge the RBK Consortium Monitoring Board for their input: Dale Abrahamson (University of Kansas Medical Center), Dennis Brown (Massachusetts General Hospital), Alison Kohan (University of Pittsburgh), Thomas Peterson (United Therapeutics), William Welch (Georgetown University), and Kaiming Ye (State University of New York).
Files
| Name | Size | Download all |
|---|---|---|
|
md5:26dc512b055c6d03b8206eb5f82e800f
|
4.2 MB | Preview Download |
Additional details
- National Institute of Diabetes and Digestive and Kidney Diseases
- DK126038
- National Institute of Diabetes and Digestive and Kidney Diseases
- DK108215
- National Institute of Diabetes and Digestive and Kidney Diseases
- DK126122
- National Institute of Diabetes and Digestive and Kidney Diseases
- DK126024
- National Institute of Diabetes and Digestive and Kidney Diseases
- DK107350
- National Institute of Diabetes and Digestive and Kidney Diseases
- DK126006
- National Institute of Diabetes and Digestive and Kidney Diseases
- BX002660
- National Institute of Diabetes and Digestive and Kidney Diseases
- DK126021
- National Institute of Diabetes and Digestive and Kidney Diseases
- F30DK123985
- National Institute of Diabetes and Digestive and Kidney Diseases
- T32GM008152
- Accepted
-
2022-02-16Accepted
- Available
-
2022-03-09Published online
- Available
-
2022-04-20Version of record
- Caltech groups
- Division of Biology and Biological Engineering
- Publication Status
- Published