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Published March 1, 2009 | Published
Journal Article Open

M-mode photoacoustic particle flow imaging


Recently, there has been growing interest in the development of photoacoustic flow measuring methods aimed to study microvascular blood flow in biological tissue. Here, we describe the M-mode photoacoustic particle flow imaging, using an optical resolution photoacoustic microscope equipped with a high-repetition-rate pulsed dye laser. We studied the flow of a diluted dyed particle suspension in a small tube embedded in a nonscattering medium as well as in a scattering medium simulating biological tissue. Potentially, the method can be applied to detect the flow speed of single red blood cells in a capillary.

Additional Information

© 2009 Optical Society of America. Received November 24, 2008; accepted December 23, 2008; posted January 29, 2009 (Doc. ID 104498); published February 26, 2009. This research is supported by the National Institutes of Health (NIH) grants R01 EB000712 and R01 NS046214. L. V. Wang has a financial interest in Endra, Inc., which did not support this work. We acknowledge Song Hu and Konstantin Maslov for their help with the experiment.

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