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Published March 1, 1972 | public
Journal Article Open

Replication of mitochondrial DNA. Circular replicative intermediates in mouse L cells


The frequency, composition, and structure of circular replicating forms of mitochondrial DNA, including two new forms described here, suggest a scheme for the mode of replication of this DNA.

Additional Information

© 1972 by the National Academy of Sciences. Contributed by Jerome Vinograd, January 3, 1972. We thank J. Edens for technical assistance and M.-T. Hsu for consultation. This investigation was supported by USPHS grants CA08014 from the National Cancer Institute and GM15328, GM00086, and GM10991 from the National Institute of General Medical Sciences. H.K. is the recipient of a postdoctoral fellowship from the Helen Hay Whitney Foundation. This is contribution no. 4399 from the Division of Chemistry and Chemical Engineering.


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