The Neural Crest in Development and Evolution by Brian K. Hall [Book Review]

The neural crest is a fascinating population of cells that is unique to craniates. These cells arise as the nervous system forms. Initially, they are contiguous with the developing CNS (presumptive brain and spinal cord). Shortly after neurulation, however, they migrate away from their site of origin and undergo extensive and stereotypic movements throughout the body. Upon reaching their final destination, they differentiate into a wide array of derivatives, including much of the PNS and craniofacial skeleton, as well as some endocrine and smooth-muscle cells. Their migratory ability, extensive diversity of derivatives and accessibility to manipulation has made this cell population an excellent model system for both developmental and evolutionary studies. Furthermore, they are susceptible to abnormal development, which gives rise to notable birth defects and cancerous derivatives. Thus, the neural crest represents a cell population of great clinical importance.