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Published September 14, 2009 | Published
Journal Article Open

Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies


Photoacoustic microscopy is predominantly sensitive to optical absorption, while optical coherence tomography relies on optical backscattering. Integrating their complementary contrasts can provide comprehensive information about biological tissue. We have developed a dual-modality microscope that combines the two for studying microcirculation. Three-dimensional imaging of microvasculature and its local environment has been demonstrated at micrometer-order resolution using endogenous contrast in vivo.

Additional Information

© 2009 Optical Society of America. Received 2 Jul 2009; revised 11 Aug 2009; accepted 13 Aug 2009; published 31 Aug 2009. This work was supported in part by National Institutes of Health grants R01 CA092415, R01 NS46214 (BRP), R01 EB000712, R01 EB008085, and U54 CA136398 (NTR). We also thank Jim Ballard and Christopher Favazza for proofreading the manuscript. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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