Applications and status of gene drive in plants
Abstract
Gene drive can modify or suppress plant populations, offering solutions to challenges associated with globalization and climate change. However, common features of plant biology complicate its application. Self-limiting methods provide a controlled, reversible path forward.
Copyright and License (English)
Copyright: © 2025 Bruce A. Hay. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability (English)
Abbreviations: ClvR, Cleave and Rescue mechanism; gRNAs, guide RNAs; LOF, loss-of-function; TA, Toxin-Antidote
Conflict of Interest (English)
Competing interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: BH and members of the Hay lab are listed as inventors on Caltech patents describing ClvR-based self-sustaining gene drive (US 12,157,883 B2) and self-limiting gene drive (US 11,965,172 B2).
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Additional details
- Caltech groups
- Division of Biology and Biological Engineering (BBE)
- Publication Status
- Published