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Published March 2010 | Published
Journal Article Open

Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo


With a refined ultrasound-array-based real-time photoacoustic microscopy (UA-PAM) system, we demonstrate the feasibility of noninvasive in vivo imaging of human pulsatile dynamics. The system, capable of real-time B-scan imaging at 50Hz and high-speed 3-D imaging, is validated by imaging the subcutaneous microvasculature in rats and humans. After the validation, a human artery around the palm-wrist area is imaged, and its pulsatile dynamics, including the arterial pulsatile motion and changes in hemoglobin concentration, is monitored with 20-ms B-scan imaging temporal resolution. To our knowledge, this is the first demonstration of real-time photoacoustic imaging of human physiological dynamics. Our results show that UA-PAM can potentially enable many new possibilities for studying functional and physiological dynamics in both preclinical and clinical imaging settings.

Additional Information

© 2010 SPIE. Paper 09284SSR received Jul. 8, 2009; revised manuscript received Sep. 15, 2009; accepted for publication Sep. 22, 2009; published online Mar. 11, 2010. This work was sponsored in part by National Institutes of Health Grants U54 CA136398 (NTR), R01 EB000712, R01 NS46214 (BRP), and R01 EB008085. L.W. has a financial interest in Microphotoacoustics, Inc., and Endra, Inc., which, however, did not support this work. The authors are grateful to Christopher Favazza, Chulhong Kim, Joon-Mo Yang, Song Hu, and Todd Erpelding for beneficial discussions. They also thank Professor Jim Ballard for careful proofreading.

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