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Published February 15, 2016 | Published
Journal Article Open

Photoacoustic elastography


Elastography can noninvasively map the elasticity distribution in biological tissue, which can potentially be used to reveal disease conditions. In this Letter, we have demonstrated photoacoustic elastography by using a linear-array photoacoustic computed tomography system. The feasibility of photoacoustic elastography was first demonstrated by imaging the strains of single-layer and bilayer gelatin phantoms with various stiffness values. The measured strains agreed well with theoretical values, with an average error of less than 5.2%. Next, in vivo photoacoustic elastography was demonstrated on a mouse leg, where the fat and muscle distribution was mapped based on the elasticity contrast. We confirmed the photoacoustic elastography results by ultrasound elastography performed simultaneously.

Additional Information

© 2016 Optical Society of America. Received 29 September 2015; revised 28 November 2015; accepted 11 January 2016; posted 13 January 2016 (Doc. ID 250984); published 5 February 2016. Funding: National Institutes of Health (NIH) (DP1-EB016986, R01-CA186567, S10-RR026922); March of Dimes Foundation (22FY14486). The authors appreciate Prof. James Ballard's close reading of the manuscript. L. V. Wang has a financial interest in Endra, Inc., and Microphotoacoustics, Inc., which, however, did not support this work.

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