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Published January 1945 | Published
Journal Article Open

Improvements in the Cylinder-Plate Method for Penicillin Assay


The most widely used technique for penicillin assay is the so-called cylinder-plate method of Abraham et al. (1941), with various modifications such as those described by Foster and Woodruff (1944) and by Schmidt and Moyer (1944). In using this method for large numbers of assays we have found it advantageous from the standpoint of time involved and reproducibility of the method to use a 4 1/2 x 11 1/2 inch, rectangular, culture plate on which 40 cylinders can be placed.

Additional Information

© 1945 American Society for Microbiology. Received for publication August 30, 1944. The method reported in this paper was developed in connection with work done under the Office of Production Research and Development, War Production Board, Contract 169.

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August 19, 2023
October 23, 2023