Optical-resolution photoacoustic endomicroscopy in vivo
Abstract
Optical-resolution photoacoustic microscopy (OR-PAM) has become a major experimental tool of photoacoustic tomography, with unique imaging capabilities for various biological applications. However, conventional imaging systems are all table-top embodiments, which preclude their use in internal organs. In this study, by applying the OR-PAM concept to our recently developed endoscopic technique, called photoacoustic endoscopy (PAE), we created an optical-resolution photoacoustic endomicroscopy (OR-PAEM) system, which enables internal organ imaging with a much finer resolution than conventional acoustic-resolution PAE systems. OR-PAEM has potential preclinical and clinical applications using either endogenous or exogenous contrast agents.
Additional Information
© 2015 Optical Society of America. Received 10 Dec 2014; revised 26 Jan 2015; accepted 28 Jan 2015; published 23 Feb 2015. We thank Prof. James Ballard for his attentive reading of the manuscript. This work was sponsored in part by National Institutes of Health grants R01 CA157277, DP1 EB016986 (NIH Director's Pioneer Award), P41-EB002182, and R01 CA186567 (NIH Director's Transformative Research Award). L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. K.M. has a financial interest in Microphotoacoustics, Inc.Attached Files
Published - boe-6-3-918.pdf
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Additional details
- PMCID
- PMC4361445
- Eprint ID
- 68577
- Resolver ID
- CaltechAUTHORS:20160622-102632287
- NIH
- R01 CA157277
- NIH
- DP1 EB016986
- NIH
- P41-EB002182
- NIH
- R02 CA186567
- Created
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2016-06-23Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field