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Published September 2, 2011 | Accepted Version
Journal Article Open

Synthetic Biology: Integrated Gene Circuits


A major goal of synthetic biology is to develop a deeper understanding of biological design principles from the bottom up, by building circuits and studying their behavior in cells. Investigators initially sought to design circuits "from scratch" that functioned as independently as possible from the underlying cellular system. More recently, researchers have begun to develop a new generation of synthetic circuits that integrate more closely with endogenous cellular processes. These approaches are providing fundamental insights into the regulatory architecture, dynamics, and evolution of genetic circuits and enabling new levels of control across diverse biological systems.

Additional Information

© 2011 American Association for the Advancement of Science. The authors thank D. Sprinzak, J. Locke, J. Levine, P. Neveu, J. Young, and other members of the Elowitz lab for helpful discussions and critical reading of the manuscript. This work was supported by NIH grants 5R01GM086793, 5R01GM079771, and P50GM068763; NSF Career Award 0644463; and a Packard Fellowship.

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