CaltechAUTHORS
Published September 2004 | Version Published
Book Section - Chapter Open

Recording advances for neural prosthetics

Creators

  • 1. ROR icon California Institute of Technology
  • 2. ROR icon Huntington Hospital
  • 3. ROR icon Jet Propulsion Lab

Abstract

An important challenge for neural prosthetics research is to record from populations of neurons over long periods of time, ideally for the lifetime of the patient. Two new advances toward this goal are described, the use of local field potentials (LFPs) and autonomously positioned recording electrodes. LFPs are the composite extracellular potential field from several hundreds of neurons around the electrode tip. LFP recordings can be maintained for longer periods of time than single cell recordings. We find that similar information can be decoded from LFP and spike recordings, with better performance for state decodes with LFPs and, depending on the area, equivalent or slightly less than equivalent performance for signaling the direction of planned movements. Movable electrodes in microdrives can be adjusted in the tissue to optimize recordings, but their movements must be automated to be a practical benefit to patients. We have developed automation algorithms and a meso-scale autonomous electrode testbed, and demonstrated that this system can autonomously isolate and maintain the recorded signal quality of single cells in the cortex of awake, behaving monkeys. These two advances show promise for developing very long term recording for neural prosthetic applications.

Additional Information

© 2004 IEEE. Reprinted with permission. We thank Tessa Yao for administrative support, Betty Grieve, Kelsie Pejsa, and Lea Martel for technical support, and Viktor Shcherbatyuk for computer support. We wish to acknowledge the support of the Defense Advanced Research Projects Agency, the National Eye Institute, the Office of Naval Research, the Boswell Foundation, the National Science Foundation, the Christopher Reeve Paralysis Foundation, and the Human Frontier Science Program.

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Additional details

Identifiers

Eprint ID
11511
Resolver ID
CaltechAUTHORS:ANDembc04

Funding

Defense Advanced Research Projects Agency (DARPA)
National Eye Institute
Office of Naval Research (ONR)
James G. Boswell Foundation
NSF
Christopher Reeve Paralysis Foundation
Human Frontier Science Program
NIH

Dates

Created
2008-08-26
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Updated
2021-11-08
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