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Published June 17, 1983 | public
Journal Article

Erythrocyte Form of Spectrin in Cerebellum: Appearance at a Specific Stage in the Terminal Differentiation of Neurons


Chicken cerebellum expresses a polypeptide antigenically and biochemically related to the alpha subunit of spectrin, an erythrocyte membrane-cytoskeletal protein. Most of this polypeptide is associated with a brain specific spectrin subunit, gamma-spectrin, and is localized in virtually all neuronal cell bodies and processes. Cerebellum also expresses polypeptides antigenically related to the beta subunits of erythrocyte spectrin and these are also found in association with cerebellar alpha-spectrin but are confined to the plasmalemma of the neuronal cell bodies. This suggests that there is a mechanism for segregating different spectrin complexes into distinct membrane domains within a single cell.

Additional Information

© 1983 American Association for the Advancement of Science. Received 14 July 1983; accepted 14 October 1983. This work was supported by grants from the National Institutes of Health (GM-06965 and a research career development award to E.L.), the National Science Foundation and Muscular Dystrophy Association, and a Cancer Research Campaign fellowship from the International Union Against Cancer (to W.J.N.).

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August 19, 2023
October 19, 2023