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Published November 15, 1991 | public
Journal Article

Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo


We describe the isolation of seven different protein-tyrosine phosphatase (PTPase) cDNAs from Drosophila embryos, three of which are primarily expressed in the central nervous system (CNS). The CNS-specific PTPases include the previously sequenced DLAR, as well as two novel PTPases (denoted DPTP_(10D) and DPTP_(99A)), which have extracellular domains consisting of multiple fibronectin type III repeats. Each of the Drosophila sequences is most closely related to a different human PTPase. The three PTPase mRNAs are expressed in different patterns of cells in the ventral nerve cord, and all three proteins are restricted to axons. DLAR and DPTP_(99A) are apparently expressed on most or all axons, while DPTP_(10D) is primarily localized to the anterior commissure and its junctions with the longitudinal tracts.

Additional Information

© 1991 Published by Elsevier Inc. Received July 23, 1991; revised September 6, 1991. We thank Susan Ou and the Caltech monoclonal antibody facility for performing the MAb fusions, Susan Parkhurst for advice on in situ hybridization, Bruce Hamilton for discussions on transposon-facilitated sequencing and comments on the manuscript, Nicholas Brown for cDNA libraries, Yu-Chun Kuo for technical assistance, and Iswar Hariharan, Mark Seeger, and William Chia for communicating data before publication. S. S. T. was supported by a postdoctoral grant from the Bing Foundation. This work was supported by National Institutes of Health grant #NS28182 to K. Z., as well as by Basil O'Connor Starter Scholar Research Award #5-816 from the March of Dimes Birth Defects Foundation, a Pew Scholars Award, and a McKnight Scholars Award. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC Section 1734 solely to indicate this fact.

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