Black silicon as a multifunctional material for medical implants: First demonstrated use in in-vivo intraocular pressure sensing
Abstract
We report the first in vivo demonstrated use of multifunctional black silicon (b-Si) on medical implants. B-Si is integrated onto the surface of a highly miniaturized sub-mm implantable intraocular pressure (IOP) sensor. This integration has significantly improved sensor signal-to-noise ratio (SNR) through the suppression of background noise as well as durability through minimized device biofouling. The incorporation of b-Si has enabled the use of a slit-lamp, the most widely used clinical ophthalmic microscope, for real-time IOP measurements on fully awake rabbits at a world-record 12-cm readout distance. Furthermore, b-Si has shown remarkable antifouling properties during a 6-month in vivo study by minimizing tissue proliferation and encapsulation on the ocular implant, promising much improved long-term implant serviceability.
Additional Information
© 2017 IEEE. This work was funded by the National Institute of Health (NIH) (Grant No. EY024582), HMRI Investigator Award, Caltech CI2, and Powell Foundation Award.Additional details
- Eprint ID
- 84122
- Resolver ID
- CaltechAUTHORS:20180105-095739798
- NIH
- EY024582
- Heritage Medical Research Institute
- Caltech Innovation Initiative (CI2)
- Charles Lee Powell Foundation
- Created
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2018-01-05Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field
- Caltech groups
- Heritage Medical Research Institute