Exploring in vivo combinatorial chemo-immunotherapy: Addressing p97 suppression and immune reinvigoration in pancreatic cancer with tumor microenvironment-responsive nanoformulation
Abstract
Copyright and License
© 2024 The Authors. Published by Elsevier Masson SAS Under a Creative Commons license.
Acknowledgement
This project received financial support through grants from the National Science and Technology Council (NSTC) of Taiwan (MOST 110–2320-B-A49A-510-MY3 and MOST 107–2320-B-010–015-MY3), the National Yang Ming Chiao Tung University and Cheng Hsin General Hospital (CY113–15 and CY112–14), and the Veterans General Hospitals and University System of Taiwan (VGHUST113-G2–2–3 and VGHUST112-G2–2–3). We extend our appreciation to the Small Animal Imaging Core Facility of the Brain Research Center at National Yang Ming Chiao Tung University and Taiwan Animal Consortium for the technical support in Bruker 7 T PET/MR. In addition, we acknowledge the National Laboratory Animal Center, National Applied Research Laboratories in Taipei, Taiwan, for providing the experimental animals.
Contributions
Yu-Li Lo: Writing – review & editing, Writing – original draft, Visualization, Validation, Supervision, Resources, Project administration, Methodology, Investigation, Funding acquisition, Data curation, Conceptualization. Ching-Yao Li: Methodology, Investigation. Li-Ling Wu: Data curation. Chun-Jung Chen: Conceptualization. Tsui-Fen Chou: Conceptualization. Ching-Ping Yang: Writing – review & editing. Yih-Hsin Chang: Conceptualization.
Data Availability
Ethics
All animal protocols received approval from the Institutional Animal Care and Use Committee (IACUC) of National Yang Ming Chiao Tung University (approval number 1100411r). All in vivo investigations adhered to the criteria authorized by the IACUC.
Conflict of Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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Additional details
- National Science and Technology Council
- 110–2320-B-A49A-510-MY3
- National Science and Technology Council
- 107–2320-B-010–015-MY3
- National Yang Ming Chiao Tung University
- Cheng Hsin General Hospital
- CY113–15
- Cheng Hsin General Hospital
- CY112–14
- University System of Taiwan
- VGHUST113-G2–2–3
- University System of Taiwan
- VGHUST112-G2–2–3
- Caltech groups
- Division of Biology and Biological Engineering, Tianqiao and Chrissy Chen Institute for Neuroscience