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Published April 1, 1969 | public
Journal Article Open

Complex mitochondrial DNA in leukemic and normal human myeloid cells


Mitochondrial DNA's from the peripheral blood of 14 patients with granulocytic leukemia contained a circular dimer form. No such structure could be found in M DNA's from three patients with nonmalignant proliferations of granulocytes. The frequency of the circular dimer form is reduced upon treatment with antileukemic drugs. The above results suggest that a significant relation exists between the formation and presence of the circular dimer M DNA form and granulocytic leukemia in man.

Additional Information

© 1969 by the National Academy of Sciences. Communicated January 13, 1969. It is a pleasure to thank Dr. R.L. Teplitz, City of Hope Medical Center, Duarte, California, for advice and several helpful discussions. We also thank Dr. Teplitz; Dr. H.R. Bierman, Beverly Hills, California; Professor W.C. Moloney, Peter Bent Brigham Hospital, Boston, Massachusetts; Dr. R.D. Lewis, Huntington Hospital, Pasadena, California; and Dr. R. Boardman, San Marino, California, for blood samples and clinical diagnoses. We are grateful to Marlyn Teplitz for expert technical assistance and to Rebecca Burress for aid in preparation of the manuscript. This work was supported by grants GM 15327 and CA 08014 from the USPHS. This is contribution #3793 from the Division of Chemistry and Chemical Engineering.


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