CaltechAUTHORS
Published February 1991 | Version public
Journal Article Metadata-only

Effects of Mesodermal Tissues on Avian Neural Crest Cell Migration

Creators

  • 1. ROR icon University of California, Irvine
  • 2. ROR icon University of Oxford

Abstract

We have used microsurgical techniques to investigate the effects of embryonic mesodermal tissues on the pattern of chick neural crest cell migration in the trunk. Segmental plate or lateral plate mesenchyme was transplanted into regions encountered by neural crest cells. We found that neural crest cells are able to migrate through lateral plate mesenchyme but not through segmental plate tissue until this tissue differentiates into a sclerotome. After this stage, segmental migration is controlled by the subdivision of the sclerotome into a rostral and a caudal half: when the rostrocaudal orientation of the sclerotomes is reversed by rotating the segmental plate 180° about its rostrocaudal axis, neural crest cells migrate through the portion of the sclerotome that was originally rostral.

Additional Information

© 1991 Academic Press, Inc. Accepted 9 October 1990. This study was funded by USPHS Grant HD 15527 and a grant from the Muscular Dystrophy Association to M.B.F. and by a travel grant from the Wellcome Trust to C.D.S. M.B.F. is a Sloan Research Fellow.

Additional details

Identifiers

Eprint ID
65138
DOI
10.1016/0012-1606(91)90071-A
Resolver ID
CaltechAUTHORS:20160307-141030790

Related works

Describes
10.1016/0012-1606(91)90071-A (DOI)

Funding

U.S. Public Health Service (USPHS)
HD-15527
Muscular Dystrophy Association
Wellcome Trust
Alfred P. Sloan Foundation

Dates

Created
2016-03-14
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Updated
2021-11-10
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