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Published January 2014 | Published
Journal Article Open

Photoacoustic measurement of the Grüneisen parameter of tissue


The Grüneisen parameter, a constitutive parameter in photoacoustics, is usually measured from isobaric thermal expansion, which may not be valid for a biological medium due to its heterogeneity. Here, we directly measured the Grüneisen parameter by applying photoacoustic spectroscopy. Laser pulses at wavelengths between 460 and 1800 nm were delivered to tissue samples, and photoacoustic signals were detected by flat water-immersion ultrasonic transducers. Least-squares fitting photoacoustic spectra to molar optical absorption spectra showed that the Grüneisen parameter was 0.81±0.05 (mean±SD) for porcine subcutaneous fat tissue and 0.69±0.02 for porcine lipid at room temperature (22°C). The Grüneisen parameter of a red blood cell suspension was linearly related to hemoglobin concentration, and the parameter of bovine serum was 9% greater than that of water at room temperature.

Additional Information

© 2014 SPIE. Paper 130780R received Oct. 29, 2013; revised manuscript received Dec. 23, 2013; accepted for publication Dec. 31, 2013; published online Jan. 28, 2014. We thank Prof. James Ballard for his close reading of the manuscript. This work was sponsored in part by National Institutes of Health grants DP1 EB016986 (NIH Director's Pioneer Award), R01 EB016963, R01 CA134539, U54 CA136398, R01 EB010049, R01 CA157277, and R01 CA159959. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. K.M. has a financial interest in Microphotoacoustics, Inc., which, however, did not support this work.

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