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Published February 2014 | Published
Journal Article Open

Photoacoustic thermography of tissue


Photoacoustic (PA) techniques can measure temperature in biological tissues because PA signal amplitude is sensitive to tissue temperature. So far, temperature-measuring PA techniques have focused on sensing of temperature changes at a single position. In this work, we photoacoustically measured spatial distribution of temperature in deep tissue. By monitoring the temperature at a single position using a thermocouple, the relationship between the PA signal amplitude and the actual temperature was determined. The relationship was then used to translate a PA image into a temperature map. This study showed that it is possible to calibrate the system for the temperature range of hyperthermia using single-point measurements over a smaller temperature range. Our experimental results showed a precision of −0.8±0.4°C (mean±standard error) in temperature measurement, and a spatial resolution as fine as 1.0 mm. PA techniques can be potentially applied to monitor temperature distribution deep in tissue during hyperthermia treatment of cancer.

Additional Information

© 2014 SPIE. Paper 130797R received Nov. 6, 2013; revised manuscript received Dec. 28, 2013; accepted for publication Dec. 31, 2013; published online Feb. 12, 2014. The authors appreciate James Ballard's close reading of this paper. We thank Guo Li, Junjie Yao, and Lidai Wang for valuable discussions. This work was sponsored by NIH Grants Nos. R01 CA134539, DP1 EB016986 (NIH Director's Pioneer Award), R01 EB016963, U54 CA136398, R01 CA157277, and R01 CA159959. L.V. Wang has a financial interest in Endra, Inc., and Microphotoacoustics, Inc., which, however, did not support this work.

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