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Published August 22, 2003 | public
Journal Article

Long-Range DNA Charge Transport


The stack of base pairs within double helical DNA has been shown to mediate charge transport reactions. Charge transport through DNA can result in chemistry at a distance, yielding oxidative DNA damage at a site remote from the bound oxidant. Since DNA charge transport chemistry depends on coupling within the stacked base pair array, this chemistry is remarkably sensitive to sequence-dependent DNA structure and dynamics. Here, we discuss different features of DNA charge transport chemistry, including applications as well as possible biological consequences and opportunities.

Additional Information

© 2003 American Chemical Society. Received March 17, 2003. Publication Date (Web): August 15, 2003. We are grateful to the NIH for financial support and to our many co-workers and collaborators for their contributions. J.K.B. also thanks the colleagues she has had who helped to inspire the exploration of this chemistry.

Additional details

August 19, 2023
October 17, 2023