Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published March 23, 2011 | Supplemental Material + Accepted Version
Journal Article Open

Single-Step Charge Transport through DNA over Long Distances


Quantum yields for charge transport across adenine tracts of increasing length have been measured by monitoring hole transport in synthetic oligonucleotides between photoexcited 2-aminopurine, a fluorescent analogue of adenine, and N_2-cyclopropyl guanine. Using fluorescence quenching, a measure of hole injection, and hole trapping by the cyclopropyl guanine derivative, we separate the individual contributions of single- and multistep channels to DNA charge transport and find that with 7 or 8 intervening adenines the charge transport is a coherent, single-step process. Moreover, a transition occurs from multistep to single-step charge transport with increasing donor/acceptor separation, opposite to that generally observed in molecular wires. These results establish that coherent transport through DNA occurs preferentially across 10 base pairs, favored by delocalization over a full turn of the helix.

Additional Information

© 2011 American Chemical Society. Received: August 5, 2010. Published: February 24, 2011. We are grateful to the National Institutes of Health (GM49216) for their support. We also thank the Caltech SURF program for a summer undergraduate fellowship (S.M.W.).

Attached Files

Accepted Version - nihms277098.pdf

Supplemental Material - ja107033v_si_001.pdf


Files (1.9 MB)
Name Size Download all
1.8 MB Preview Download
180.6 kB Preview Download

Additional details

August 19, 2023
October 23, 2023