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Published March 1, 1968 | public
Journal Article Open

Cytoplasmic DNA in the unfertilized sea urchin egg: Physical properties of circular mitochondrial DNA and the occurrence of catenated forms


The mitochondrial DNA in the unfertilized egg of the sea urchin Lytechinus pictus is present in an amount approximately seven times that of the haploid nuclear DNA.(1) The mitochondrial DNA has a higher buoyant density than the nuclear DNA and consists of circular duplex molecules of a uniform size of about 5µ. The circular DNA has been recovered(1) in both the intact (closed) and nicked (open) states characteristic of the circular duplex viral DNA's(2) and the mitochondrial DNA's from birds and mammals.(3, 4)

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© 1968 by the National Academy of Sciences. Communicated by Robert L. Sinsheimer, January 5, 1968. The authors wish to thank J. Jordan, R. Radloff, and R. Watson for advice and assistance, and P. N. Redington and E. E. Vivanco for technical contributions. This work was supported by grants GM-15327, 8R01 HD 03476, and CA-08014 from the U.S. Public Health Service and grant GB-28 from the National Science Foundation. Contribution 3628 from the Laboratories of Chemistry, California Institute of Technology, Pasadena, California.


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