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Published February 29, 2008 | Published
Book Section - Chapter Open

Optofluidic microscope: a complete on-chip imaging device


This paper reports a complete on-chip high resolution lensless imaging device based on the optofluidic microscopy method, which can form a vital optical microscopy component in a wide range of lab-on-a-chip systems. This imaging device does not use any lens elements and yet is capable of resolution comparable to that of a conventional microscope with a 20× objective. We demonstrate the use of the device for Caenorhabditis elegans and microsphere imaging at a resolution of ~ 1 μm with an imaging time of ~2 sec. The fabrication of this on-chip imaging device is fully compatible with existing semiconductor and microfluidic technologies, so the device can be massively fabricated and integrated into microsystems to form compact and low-cost total analysis systems for biological and colloidal studies.

Additional Information

© 2008 Society of Photo-Optical Instrumentation Engineers (SPIE). We are grateful for the generous help from Professor Axel Scherer. The assistance from Caltech Watson cleanroom is well appreciated. This project is funded by DARPA's center for optofluidic integration and Coulter Foundation Career Award.

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