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Published October 2016 | Published + Accepted Version
Journal Article Open

Toward community standards and software for whole-cell modeling


Whole-cell (WC) modeling is a promising tool for biological research, bioengineering, and medicine. However, substantial work remains to create accurate, comprehensive models of complex cells. Methods: We organized the 2015 Whole-Cell Modeling Summer School to teach WC modeling and evaluate the need for new WC modeling standards and software by recoding a recently published WC model in SBML. Results: Our analysis revealed several challenges to representing WC models using the current standards. Conclusion: We, therefore, propose several new WC modeling standards, software, and databases. Significance:We anticipate that these new standards and software will enable more comprehensive models.

Additional Information

© 2016 IEEE. This work is licensed under a Creative Commons Attribution 3.0 License. Manuscript received August 3, 2015; accepted April 18, 2016. Date of publication June 10, 2016; date of current version September 16, 2016. The Rostock and Utah meetings were supported by the Volkswagen Foundation (Grant 88495 to D. Waltemath and F. Schreiber). The work of J. R. Karr was supported by the James S. McDonnell Foundation Postdoctoral Fellowship Award in Studying Complex Systems and the National Science Foundation under Grant 1548123. The work of J. Cursons was supported by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology through Project CE140100036.

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August 20, 2023
October 20, 2023