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Published January 15, 2015 | public
Journal Article Open

Evolutionarily conserved role for SoxC genes in neural crest specification and neuronal differentiation


Members of the Sox family of transcription factors play a variety of critical developmental roles in both vertebrates and invertebrates. Whereas SoxBs and SoxEs are involved in neural and neural crest development, respectively, far less is known about members of the SoxC subfamily. To address this from an evolutionary perspective, we compare expression and function of SoxC genes in neural crest cells and their derivatives in lamprey (Petromyzon marinus), a basal vertebrate, to frog (Xenopus laevis). Analysis of transcript distribution from reveals conservation of lamprey and X. laevis SoxC expression in premigratory neural crest, branchial arches, and cranial ganglia. Moreover, morpholino-mediated loss-of-function of selected SoxC family members demonstrates essential roles in aspects of neural crest development in both organisms. The results suggest important and conserved functions of SoxC genes during vertebrate evolution and a particularly critical, previously unrecognized role in early neural crest specification.

Additional Information

© 2014 Elsevier Inc. Received 29 September 2013, Revised 6 August 2014, Accepted 19 September 2014, Available online 5 October 2014. We thank Natalya Nikitina for the lamprey neurogenin probe, and Shuyi Nie for sharing her frog expertise, NIH Caltech Training Grant, the Caltech SURF for generous support of BRU. MSC was supported by the Pew Fellows Program in the Biomedical Sciences and a Caltech Cell Center fellowship from the Moore Foundation. This work was supported by NIH Grants DE017911 and NS086907 to MEB.

Attached Files

Supplemental Material - mmc1.pdf

Accepted Version - nihms-633361.pdf


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August 22, 2023
August 22, 2023