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Published December 1942 | public
Journal Article

The Serological Properties of Simple Substances. I. Precipitation Reactions between Antibodies and Substances Containing Two or More Haptenic Groups


The problem of obtaining from precipitation experiments evidence about the structure of antibodies and the nature of serological reactions is obviously greatly simplified by the replacement of protein antigens by simple substances of known structure. For this reason we began and are carrying on an extensive program of investigation of the reactions of simple substances with antisera. In this paper we report the quantitative study of the precipitin reaction for twenty simple substances containing two or more haptenic groups, and the results of tests of seven substances containing one group. It is found that the observations support the framework theory of serological precipitates.

Additional Information

© 1942 American Chemical Society. Received July 6, 1942. We are grateful to the Rockefeller Foundation for financial support of this work. We wish to thank Mr. Paul Faust and Mr. Shelton Steinle for their assistance in carrying out analyses, and Mr. David Brown for the preparation of phenylarsonic acid.

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