Antigen-specific age-related memory CD8 T cells induce and track Alzheimer's-like neurodegeneration
Creators
-
Panwar, Akanksha
-
Rentsendorj, Altan
- Jhun, Michelle
- Cohen, Robert M.
- Cordner, Ryan
-
Gull, Nicole
-
Pechnick, Robert N.
- Duvall, Gretchen
- Mardiros, Armen
- Golchian, David
- Schubloom, Hannah
-
Jin, Lee-Way
-
Van Dam, Debby
-
Vermeiren, Yannick
-
De Reu, Hans
-
De Deyn, Peter Paul
-
Raskatov, Jevgenij A.
-
Black, Keith L.
-
Irvin, Dwain K.
- Williams, Brian A.
-
Wheeler, Christopher J.
Abstract
Copyright and License
© 2024 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
Acknowledgement
Contributions
R.C., R.N.P., J.A.R., D.K.I., B.A.W., and C.J.W. designed research; A.P., A.R., M.J., R.M.C., R.C., N.G., R.N.P., G.D., A.M., D.G., L.-W.J., D.V.D., Y.V., H.D.R., P.P.D.D., D.K.I., B.A.W., and C.J.W. performed research; A.R., R.C., R.N.P., L.-W.J., Y.V., H.D.R., P.P.D.D., K.L.B., D.K.I., B.A.W., and C.J.W. contributed new reagents/analytic tools; A.P., A.R., M.J., R.M.C., R.C., N.G., R.N.P., G.D., A.M., H.S., D.V.D., Y.V., H.D.R., P.P.D.D., D.K.I., B.A.W., and C.J.W. analyzed data; R.N.P., L.-W.J., and P.P.D.D. advised on paper framing & design; J.A.R. facilitated collaborations, advised on paper framing & design; K.L.B. and C.J.W. facilitated collaborations, supervised facilities and personnel; and A.P., A.R., R.C., and C.J.W. wrote the paper.
Data Availability
Conflict of Interest
C.J.W. is the author of patents PCT/US2016/049598, WO2017/040594, and PCT/US2019/017879. R.C. and K.L.B. are co-authors on patent PCT/US2019/017879. PCT/US2016/049598 and WO 2017/040594 are licensed by Cedars-Sinai Medical Center to T-Neuro Pharma, Inc. C.J.W. has received salary and ownership interest in T-Neuro Pharma, Inc.
Files
panwar-et-al-2024-antigen-specific-age-related-memory-cd8-t-cells-induce-and-track-alzheimer-s-like-neurodegeneration.pdf
Files
(14.8 MB)
Name | Size | Download all |
---|---|---|
md5:aaf8a5f6831c5549fbf0124193d97149
|
4.2 MB | Preview Download |
md5:adfa748896dff8d24f439701fc7c99af
|
10.6 MB | Preview Download |
Additional details
Identifiers
- ISSN
- 1091-6490
Related works
- Is new version of
- Discussion Paper: 10.1101/2024.01.22.576704 (DOI)
- Discussion Paper: PMC10849535 (PMCID)
Funding
- National Institutes of Health
- P30AG10129
- National Institutes of Health
- R21NSO54162
- National Institutes of Health
- R21AG033394
- Cedars-Sinai Medical Center
- Joseph Drown Foundation