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Published June 1, 2022 | Submitted
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Transcranial photoacoustic computed tomography of human brain function


Herein we report the first in-human transcranial imaging of brain function using photoacoustic computed tomography. Functional responses to benchmark motor tasks were imaged on both the skull-less and the skull-intact hemispheres of a hemicraniectomy patient. The observed brain responses in these preliminary results demonstrate the potential of photoacoustic computed tomography for achieving transcranial functional imaging.

Additional Information

We thank former lab members Konstantin Maslov, Xiaoyun Yuan, and Junhui Shi for their contribution towards building the system. This work was sponsored by the United States National Institutes of Health (NIH) grants U01 NS099717 (BRAIN Initiative), S10-OD025312, R01 NS102213, and R35 CA220436. Contributions. L.V.W., C.Y.L., Y.Z., S.N. and J.J.R. designed the study. L.L., S.N., Y.Z., and X.T. built and modified the system hardware. S.N. and Y.Z. developed and modified the control program. P.H., and S.N. developed the structural and functional reconstruction algorithms. Y.Z., K.S., S.N., and J.J.R. performed the PACT experiments. K.B.J. performed the MRI experiments. K.S., Y.Z., S.N., C.Y.L., D.J.W. and L.V.W. analyzed and interpreted the data. J.J.R. and C.Y.L. recruited the participants. Y.Z., S.N., K.S., and J.J.R. wrote the manuscript with input from all authors. L.V.W. revised the manuscript. L.V.W., C.Y.L. and D.J.W. supervised the study. Data availability. The data that support the findings of this study are provided within the paper and its supplementary material. Code availability. The reconstruction algorithm and data processing methods can be found in Methods. The reconstruction code is not publicly available because it is proprietary and is used in licensed technologies. Competing interests. L.V.W. has a financial interest in Microphotoacoustics Inc., CalPACT LLC, and Union Photoacoustic Technologies Ltd., which, however, did not support this work.

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August 20, 2023
October 24, 2023