Biochemistry and neuroscience: the twain need to meet
Neuroscience has come to mean the study of electrophysiology of neurons and synapses, micro and macro-scale neuroanatomy, and the functional organization of brain areas. The molecular axis of the field, as reflected in textbooks, often includes only descriptions of the structure and function of individual channels and receptor proteins, and the extracellular signals that guide development and repair. Studies of cytosolic 'molecular machines', large assemblies of proteins that orchestrate regulation of neuronal functions, have been neglected. However, a complete understanding of brain function that will enable new strategies for treatment of the most intractable neural disorders will require that in vitro biochemical studies of molecular machines be reintegrated into the field of neuroscience.
© 2017 Elsevier Ltd. Available online 1 February 2017. The author's work has been funded by the Allen and Lenabelle Davis Foundation, the Hicks Foundation for Alzheimer's Research, and by grants from the Gordon and Betty Moore Foundation (Center for Integrative Study of Cell Regulation), the National Institutes of Health, the National Science Foundation, and the Beckman Institute. Conflict of interest statement: Nothing declared.
Accepted Version - nihms845174.pdf