Published October 20, 2010
| Accepted Version
Journal Article
Open
Rapid synthesis of an electron-deficient t-BuPHOX ligand: cross-coupling of aryl bromides with secondary phosphine oxides
Abstract
Herein an efficient and direct copper-catalyzed coupling of oxazoline-containing aryl bromides with electron-deficient secondary phosphine oxides is reported. The resulting tertiary phosphine oxides can be reduced to prepare a range of PHOX ligands. The presented strategy is a useful alternative to known methods for constructing PHOX derivatives.
Additional Information
© 2010 Elsevier Ltd. Received 13 May 2010; revised 11 August 2010; accepted 12 August 2010. Available online 17 August 2010. This publication is based on the work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Additionally, the authors wish to thank NIH-NIGMS (R01 GM 080269-01), the German Academic Exchange Service (DAAD, postdoctoral fellowship to J.S.), Abbott Laboratories, Amgen, the Gordon and Betty Moore Foundation, and Caltech for financial support.Attached Files
Accepted Version - nihms230237.pdf
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Additional details
- PMCID
- PMC2976555
- Eprint ID
- 20648
- DOI
- 10.1016/j.tetlet.2010.08.039
- Resolver ID
- CaltechAUTHORS:20101103-104745366
- King Abdullah University of Science and Technology (KAUST)
- KUS-11-006-02
- NIH
- R01GM080269-01
- Deutscher Akademischer Austauschdienst (DAAD)
- Abbott Laboratories
- Amgen
- Gordon and Betty Moore Foundation
- Caltech
- Created
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2010-11-03Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field