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Published February 23, 1996 | public
Journal Article

Receptor Tyrosine Phosphatases Are Required for Motor Axon Guidance in the Drosophila Embryo


The receptor tyrosine phosphatases DPTP69D and DPTP99A are expressed on motor axons in Drosophila embryos. In mutant embryos lacking DPTP69D protein, motor neuron growth cones stop growing before reaching their muscle targets, or follow incorrect pathways that bypass these muscles. Mutant embryos lacking DPTP99A are indistinguishable from wild type. Motor axon defects in dptp69D dptp99A double mutant embryos, however, are much more severe than in embryos lacking only DPTP69D. Our results demonstrate that DPTP69D and DPTP99A are required for motor axon guidance and that they have partially redundant functions during development of the neuromuscular system.

Additional Information

© 1996 Cell Press. Published by Elsevier Inc. We thank Jonathan Bradley, Barry Condron, Bruce Hamilton, Haig Keshishian, and David Van Vactor for helpful discussions; Eugenia Popova and Maria Dolph for technical assistance with screening dptp69D mutations; Paul Patterson and members of the Zinn group for comments on the manuscript; Susan Shepherd and Yuh Nung Jan for the A5 line; Iswar Hariharan for the Df(3R)^(R3) line; Corey Goodman for antibodies; Bill Fisher and Susan Halsell for help with germline transformation; and Neil Krueger, David Van Vactor, Corey Goodman, and Haruo Saito for communicating data prior to publication. This work was supported by National Institutes of Health (NIH) grants NS28182 to K. Z. and GM35252 to L. S. B. G.; L. S. B. G. is an Investigator of the Howard Hughes Medical Institute. C. J. D. was supported by an American Cancer Society postdoctoral fellowship. J. G. G. was supported by an NIH postdoctoral fellowship.

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