Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published 1983 | Published
Journal Article Open

Molecular Events in the Synthesis and Assembly of a Nicotinic Acetylcholine Receptor


The acetylcholine receptor (AChR) has proven the most accessible model system for structure-function studies of a transmitter-activated ion channel (Karlin 1980; Conti-Tronconi and Raftery 1982). However, it also presents a good opportunity to study molecular events in the assembly of a multi-subunit integral membrane protein. Moreover, the synthesis of AChR is regulated during development, both by trophic factors (Jessel et al, 1979) and by activity (Brockes and Hall 1975). To understand the mechanistic bases of these regulatory influences, it would be helpful to know all the molecular events and intermediates in AChR biogenesis. We can presume that these events encompass gene transcription, mRNA processing and transport out of the nucleus, translation, subunit assembly, and intracellular transport of the subunits. The following discussion will concern what we have learned about the stages including and following mRNA translation.

Additional Information

© 1983 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, http://creativecommons.org/licenses/by-nc/4.0/) This work was supported by a National Science Foundation predoctoral fellowship (to D.J.A.) and a grant from the Muscular Dystrophy Foundation. We thank Drs. Arthur Karlin and Reid Gilmore for helpful discussions during the course of this work.

Attached Files

Published - Anderson_1983p125.pdf


Files (6.5 MB)
Name Size Download all
6.5 MB Preview Download

Additional details

August 19, 2023
October 23, 2023