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Published April 2016 | public
Book Section - Chapter

MEMS oxygen transport device for islet transplantation in the subcutaneous site


This paper presents a new MEMS approach of maintaining islet oxygenation for subcutaneous islet transplantation therapy of type 1 diabetes by engineering a MEMS oxygen transport device. A device is designed and fabricated. Bench-top testing and computational modeling of the device have demonstrated that it would provide sufficient oxygen to prevent hypoxia-induced islet death and maintain the functional metabolic activity of glucose-simulated insulin secretion for islets transplanted subcutaneously.

Additional Information

© 2016 IEEE. This work is financially supported by City of Hope. The authors gratefully acknowledge the help of all the members from the Caltech Micromachining Lab and City of Hope's Diabetes and Metabolic Researches Department.

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August 22, 2023
October 23, 2023