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Published November 19, 2008 | Accepted Version + Supplemental Material
Journal Article Open

Redmond Red as a Redox Probe for the DNA-Mediated Detection of Abasic Sites


Redmond Red, a fluoropore containing a redox-active phenoxazine core, has been explored as a new electrochemical probe for the detection of abasic sites in double-stranded DNA. The electrochemical behavior of Redmond Red-modified DNA at gold surfaces exhibits stable, quasi-reversible voltammetry with a midpoint potential centered around −50 mV versus NHE. Importantly, with Redmond Red positioned opposite an abasic site within the DNA duplex, the electrochemical response is significantly enhanced compared to Redmond Red positioned across from a base. Redmond Red, reporting only if well-stacked in the duplex, represents a sensitive probe to detect abasic sites electrochemically in a DNA-mediated reaction.

Additional Information

Copyright © 2008 American Chemical Society. Received August 6, 2008; Revised Manuscript Received September 9, 2008. Publication Date (Web): October 3, 2008. We are grateful to the National Institutes of Health (GM 61077) for their financial support.

Attached Files

Accepted Version - nihms-91115.pdf

Supplemental Material - BUZbc08supp.pdf


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