Published July 12, 2004
| Supplemental Material
Journal Article
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Alternative Translations of a Single RNA Message: An Identity Switch of (2S,3R)-4,4,4-Trifluorovaline between Valine and Isoleucine Codons
Abstract
Changed in translation: Bacterial expression hosts can be engineered so that a single RNA message can be read in different ways depending on the relative rates of competing aminoacylation reactions. The (2S,3R)-4,4,4-trifluorovaline can be assigned either to isoleucine or to valine codons according to whether the bacterial host overexpresses the isoleucyl- or the valyl-tRNA synthetase (IleRS and ValRS, respectively; see scheme).
Additional Information
© 2004 Wiley VCH. Issue published online: 7 JUL 2004. Article first published online: 21 JUN 2004. Manuscript Received: 17 FEB 2004. This work was supported by the National Institutes of Health (grant nos. GM65500 and GM62523), by a National Sciences Foundation CAREER award (CHE-0236846), and by the National Science Foundation Center for Science and Engineering of Materials at the California Institute of Technology.Attached Files
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Additional details
- Eprint ID
- 53960
- Resolver ID
- CaltechAUTHORS:20150121-144351506
- GM65500
- NIH
- GM62523
- NIH
- CHE-0236846
- NSF
- Created
-
2015-01-21Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field