CaltechAUTHORS
Published October 2025 | Version Published
Journal Article Metadata-only

Wearable biomolecular sensing nanotechnologies in chronic disease management

Creators

  • 1. ROR icon California Institute of Technology
  • 2. ROR icon Northwestern University
  • 3. ROR icon Chan Zuckerberg Biohub Chicago
  • 4. ROR icon University of Toronto

Abstract

Over the past decade, consumer wearable sensors have become increasingly ubiquitous in health monitoring, enabling the widespread tracking of key biophysical parameters. The transition towards next-generation body-interfaced biomolecular sensing technologies, fuelled by the integration of reagentless sensing strategies with advanced nanomaterials, marks the next substantial leap forward. These innovations enable unobtrusive, multimodal monitoring of both physiological parameters and biochemical disease markers in real time. This Review examines the current generation of body-interfaced biomolecular sensing technologies, with a particular emphasis on materials innovation and nanotechnological advancements, and discusses their pivotal role in chronic disease monitoring. The discussion extends to the challenges and prospects in this rapidly evolving field, highlighting the potential for materials-focused approaches to transform the landscape of chronic disease monitoring and management with body-interfaced bioelectronics. By harnessing the power of materials and nanotechnological innovations, these biomolecular sensing technologies promise to enhance diagnostic capabilities and foster a more proactive, personalized approach to combating these diseases.

Acknowledgement

This project was supported by the National Science Foundation (grants 2145802 and 2444815), National Institutes of Health (grants R01HL155815, R01HL165002 and R21DK13266), Army Research Office (grant W911NF-23-1-0041), American Cancer Society Research Scholar (grant RSG-21-181-01-CTPS), US Army Medical Research Acquisition Activity (grant HT9425-24-1-0249), Advanced Research Projects Agency for Health Sprint for Women’s Health (award number ARPA-H-ICHUB-24-101-504), Heritage Medical Research Institute, Natural Sciences and Engineering Research Council of Canada and Chan Zuckerberg Biohub Chicago.

Copyright and License

© Springer Nature Limited 2025

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Contributions

These authors contributed equally: Jiaobing Tu, Connor D. Flynn.

 

Conflict of Interest

The authors declare no competing interests.

Additional details

Identifiers

PMID
41094264

Funding

National Institutes of Health
R01HL155815
National Institutes of Health
R01HL165002
National Institutes of Health
R21DK13266
National Science Foundation
2145802
National Science Foundation
2444815
United States Army Research Office
W911NF-23-1-0041
American Cancer Society
RSG-21-181-01-CTPS)
United States Army Medical Research and Development Command
US Army Medical Research Acquisition Activity HT9425-24-1-0249
National Institutes of Health
Sprint for Women’s Health ARPA-H-ICHUB-24-101-504
Natural Sciences and Engineering Research Council
Chan Zuckerberg Biohub Chicago

Dates

Accepted
2025-08-06
Accepted
Available
2025-10-15
Published online

Caltech Custom Metadata

Caltech groups
Division of Engineering and Applied Science (EAS)
Publication Status
Published