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Published January 15, 2015 | Published
Journal Article Open

Establishing neural crest identity: a gene regulatory recipe


The neural crest is a stem/progenitor cell population that contributes to a wide variety of derivatives, including sensory and autonomic ganglia, cartilage and bone of the face and pigment cells of the skin. Unique to vertebrate embryos, it has served as an excellent model system for the study of cell behavior and identity owing to its multipotency, motility and ability to form a broad array of cell types. Neural crest development is thought to be controlled by a suite of transcriptional and epigenetic inputs arranged hierarchically in a gene regulatory network. Here, we examine neural crest development from a gene regulatory perspective and discuss how the underlying genetic circuitry results in the features that define this unique cell population.

Additional Information

© 2015 Published by The Company of Biologists Ltd. Funding: Work in the laboratory of M.E.B. is supported by the National Institutes of Health. M.S.-C. was funded by the Pew fellows Program in the Biomedical Sciences and by a grant from the National Institute of Dental and Craniofacial Research. Deposited in PMC for release after 12 months. Competing interests: The authors declare no competing financial interests.

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August 20, 2023
August 20, 2023