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Published September 1, 2011 | Published
Journal Article Open

Imaging with second-harmonic radiation probes in living tissue


We demonstrate that second-harmonic radiation imaging probes are efficient biomarkers for imaging in living tissue. We show that 100 nm and 300 nm BaTiO_3 nanoparticles used as contrast markers could be detected through 50 μm and 120 μm of mouse tail tissue in vitro or in vivo. Experimental results and Monte-Carlo simulations are in good agreement.

Additional Information

© 2011 Optical Society of America. Received 24 Jun 2011; revised 29 Jul 2011; accepted 29 Jul 2011; published 2 Aug 2011. The authors thank U. Haessler, M. Pasquier and W. Kilarski from M. Swartz's laboratory at EPFL for helping with the tissue and mice preparation performed by an accredited researcher under the authorization number 1954.3 delivered by the state of Vaud according to the Swiss legislation. We thank also M. Gyger for allowing the in vivo experiments, and T. Laroche from the BioImaging and Optics platform at EPFL for the imaging advices. The BaTiO3 nanoparticles were kindly provided by Paul Bowen from EPFL and Vincenzo Buscaglia from the IENI in Genoa. This project is partly supported by the National Center of Competence in Research (NCCR), Quantum Photonics.

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Published - Grange2011p17299Biomed_Opt_Express.pdf


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