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Published February 6, 2008 | Published
Book Section - Chapter Open

Optical coherence computed tomography


We proposed a novel time-resolved optical tomography, optical coherence computed tomography. It married the key concepts of time-resolved diffuse optical tomography and optical coherence tomography. Both ballistic and multiple-scattered photons were measured at multiple source-detection positions by low-coherence interferometry. It measures the reemitted light with a temporal resolution of 56 femtoseconds, which is much better than the resolution of conventional time-resolved detection systems. A light-tissue interaction model was established using the time-resolved Monte Carlo method. The optical properties were then reconstructed by solving the inverse time-resolved radiative transport problem under the first Born approximation. Our initial results showed the potential of this technology to bridge the gap between diffuse optical tomography and optical coherence tomography.

Additional Information

© 2008 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was supported in part by the National Institutes of Health grants R01 CA092415 and R01 CA106728.

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