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Published November 2, 2021 | Supplemental Material + Submitted
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Neurons in human pre-supplementary motor area encode key computations for value-based choice


Adaptive behavior in real-world environments demands that choices integrate over several variables, including the novelty of the options under consideration, their expected value, and uncertainty in value estimation. We recorded neurons from the human pre-supplementary motor area (preSMA), ventromedial prefrontal cortex (vmPFC) and dorsal anterior cingulate to probe how integration over decision variables occurs during decision-making. In contrast to the other areas, preSMA neurons not only represented separate pre-decision variables for each choice option, but also encoded an integrated utility signal and, subsequently, the decision itself. Conversely, post-decision related encoding of variables for the chosen option was more widely distributed and especially prominent in vmPFC. Our findings position the human preSMA as central to the implementation of value-based decisions.

Additional Information

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. This version posted October 28, 2021. We would like to thank the members of the O'Doherty and Rutishauser labs for discussions and feedback. We thank all subjects and their families for their participation, as well as nurses and medical staff for their work. This work was supported by National Institutes of Health Grants R01DA040011 and R01MH111425 (to J.P.O.), R01MH110831 (to U.R.), and P50MH094258 (to J.P.O. and U.R.). Author Contributions: T.G.A., J.C., U.R., and J.P.O. designed the study. T.G.A. performed the experiments. T.G.A. and J.C. analyzed the data. T.G.A., J.C., A.N.M. U.R., and J.P.O. wrote the paper. A.N.M. performed surgery and supervised clinical work. Competing interests: None. Data statement: Data and code will be deposited in a public archive upon acceptance of the manuscript.

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Submitted - 2021.10.27.466000v1.full.pdf

Supplemental Material - media-1.pdf


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August 20, 2023
August 20, 2023