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Published January 2012 | public
Journal Article

Following evolution of bacterial antibiotic resistance in real time


A new study reports the development of the 'morbidostat', a device that allows for continuous culture of bacteria under a constant drug selection pressure using computer feedback control of antibiotic concentration. This device, together with bacterial whole-genome sequencing, allowed the authors to follow the evolution of resistance-conferring mutations in Escherichia coli populations in real time, providing support for deterministic evolution of resistance in some situations.

Additional Information

© 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. Published online 27 December 2011. The authors declare no competing financial interests.

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