Published January 2012
| public
Journal Article
Following evolution of bacterial antibiotic resistance in real time
- Creators
-
Rosenthal, Adam Z.
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Elowitz, Michael B.
Abstract
A new study reports the development of the 'morbidostat', a device that allows for continuous culture of bacteria under a constant drug selection pressure using computer feedback control of antibiotic concentration. This device, together with bacterial whole-genome sequencing, allowed the authors to follow the evolution of resistance-conferring mutations in Escherichia coli populations in real time, providing support for deterministic evolution of resistance in some situations.
Additional Information
© 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. Published online 27 December 2011. The authors declare no competing financial interests.Additional details
- Eprint ID
- 29121
- DOI
- 10.1038/ng.1048
- Resolver ID
- CaltechAUTHORS:20120203-102759226
- Created
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2012-02-03Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field