CaltechAUTHORS
Published January 19, 2022 | Version Accepted Version
Journal Article Open

Ethical commitments, principles, and practices guiding intracranial neuroscientific research in humans

Creators

  • 1. ROR icon University of California, Los Angeles
  • 2. ROR icon The University of Texas Southwestern Medical Center
  • 3. ROR icon California Institute of Technology
  • 4. ROR icon University of Pennsylvania
  • 5. ROR icon University of California, San Francisco
  • 6. ROR icon Johns Hopkins University
  • 7. ROR icon University of Pittsburgh
  • 8. ROR icon Cedars-Sinai Medical Center
  • 9. ROR icon Massachusetts General Hospital
  • 10. ROR icon Harvard University
  • 11. ROR icon Baylor College of Medicine
  • 12. ROR icon The University of Texas Health Science Center at Houston

Abstract

Leveraging firsthand experience, BRAIN-funded investigators conducting intracranial human neuroscience research propose two fundamental ethical commitments: (1) maintaining the integrity of clinical care and (2) ensuring voluntariness. Principles, practices, and uncertainties related to these commitments are offered for future investigation.

Additional Information

© 2021 Elsevier. Available online 19 January 2022. The authors gratefully acknowledge the support of NIH BRAIN Initiative program officers and staff who organized the Research Opportunities in Humans (ROH) Consortium, including Karen David, Jim Gnadt, and Khara Ramos. We also acknowledge the contributions of other ROH Consortium members who contributed perspectives to the manuscript. Finally, we acknowledge the patients who have participated in relevant studies that have helped form the experiences and perspectives included in the current report. All investigators were supported by BRAIN Initiative and NIH funding, including U01 NS098961 (A.F. and N.P.), R01 MH121373 (A.F. and N.P.), U01 NS118739 (U.R. and A.M.), U01 NS117765 (E.C.), U01 NS103082 (N.S.), U01 NS117838 (N.S.), R01 MH110831 (A.M.), P50 MH094258 (R. Adolphs and A.M.), U01 NS103780 (R. Adolphs), U01 NS113339 (M.S.B.), R01 NS065395 (M.S.B.), U01 NS108922 (J.C.), U01 NS123125 (J.C.), U01 NS108930 (I.F.), R01 NS084017 (I.F.), U01 NS123127 (R. Andersen), U01 NS121472 (S.S.), U01 NS108923 (S.S.), R01 NS110424 (M.R.), U01 NS117836 (M.R.), U01 NS098969 (M.R.), R01 NS115929 (N.E.C.), UH3 NS114439 (N.E.C.), U01 DC016696 (N.E.C.), U01 NS117836 (N.E.C.), and U01 NS098981 (N.T. and N.E.C.). Additional support provided by NSF 1756473 (I.F.) and California Institute for Regenerative Medicine (CLIN2-12319, A.M.). S.S. received funding from McNair Foundation. R. Adolphs received funding from Simons Foundation Collaboration on the Global Brain. N.S. received funding from the McKnight Foundation. Author contributions. A.F. and N.P. led discussions, abstracted principles, and drafted, edited, and finalized the manuscript. H.E. documented discussions and edited the manuscript. All other authors significantly contributed to content and perspectives and edited the manuscript. Declaration of interests. S.S. is a consultant for Boston Scientific, Neuropace, and ZimmerBiomet. N.P. is a consultant for Abbott Laboratories. N.T. is a surgical committee member for the Medtronic SLATE trial.

Attached Files

Accepted Version - nihms-1814659.pdf

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Additional details

Identifiers

PMCID
PMC9417025
Eprint ID
113063
DOI
10.1016/j.neuron.2021.11.011
Resolver ID
CaltechAUTHORS:20220121-968267000

Related works

Describes
10.1016/j.neuron.2021.11.011 (DOI)

Funding

NIH
U01 NS098961
NIH
R01 MH121373
NIH
U01 NS118739
NIH
U01 NS117765
NIH
U01 NS103082
NIH
U01 NS117838
NIH
R01 MH110831
NIH
P50 MH094258
NIH
U01 NS103780
NIH
U01 NS113339
NIH
R01 NS065395
NIH
U01 NS108922
NIH
U01 NS123125
NIH
U01 NS108930
NIH
R01 NS084017
NIH
U01 NS123127
NIH
U01 NS121472
NIH
U01 NS108923
NIH
R01 NS110424
NIH
U01 NS117836
NIH
U01 NS098969
NIH
R01 NS115929
NIH
UH3 NS114439
NIH
U01 DC016696
NIH
U01 NS117836
NIH
U01 NS098981
NSF
BCS-1756473
California Institute for Regenerative Medicine (CIRM)
CLIN2-12319
Robert and Janice McNair Foundation
Simons Foundation
McKnight Foundation

Dates

Created
2022-01-24
Created from EPrint's datestamp field
Updated
2023-07-06
Created from EPrint's last_modified field

Caltech Custom Metadata

Caltech groups
Tianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering (BBE), Division of Biology and Biological Engineering (BBE)