Published May 23, 2024
| Published
Journal Article
Open
The first two blastomeres contribute unequally to the human embryo
Abstract
Copyright and License
© 2024 The Author(s). Published by Elsevier. Creative Commons Attribution (CC BY 4.0)
Acknowledgement
We thank the patients who volunteered embryos for this work. We thank Maria Luisa Pardinas, Maria José De los Santos Molina, and IVIRMA Valencia for securing access to Embryoscope movies; Mingshu Liao and Changhuei Yang for help on image preparation; and David Glover, Adiyant Lamba, and Angela Andersen for invaluable advice. Some drawings were adapted from BioRender (BioRender.com). This work was supported by the Human Science Frontiers Program (LT0022/2022-L to S.J.), the NOMIS Foundation (12540449 to M.Z.-G.), the Wellcome Trust (207415/Z/17/Z to M.Z.-G.), the Open Philanthropy Project (to M.Z.-G.), the Shuri & Kay Curci Foundation (to M.Z.-G.), and the Weston Havens Foundation (to M.Z.-G.).
Contributions
Conceptualization: S.J., M.M., and M.Z.-G.; methodology: S.J., M.M., and R.V.; software: R.V. and D.I.; formal analysis: S.J., M.M., C.K., E.M.P., L.I.-S., and R.V.; investigation: S.J., M.M., L.I.-S., and D.-Y.C.; resources: R.M., P.R., R.J.P., and M.Z.-G.; writing: S.J., M.M., and M.Z.-G.; visualization: S.J. and M.M.; supervision: D.I. and M.Z.-G.; funding acquisition: S.J., N.A., D.I., and M.Z.-G.
Code Availability
Data S1. Source code for the mathematical model presented in Figure 6.
Conflict of Interest
N.A. is the founder and CEO of Progenesis Inc.
Files
mmc1.zip
Files
(17.7 MB)
Name | Size | Download all |
---|---|---|
md5:246dc5e477cc417ebb66c55b1aad75a9
|
25.8 kB | Preview Download |
md5:f2400e74b0ad7382e0bca0a1896b4d70
|
17.7 MB | Preview Download |
Additional details
- International Human Frontier Science Program Organization
- LT0022/2022-L
- Nomis Foundation
- 12540449
- Wellcome Trust
- 207415/Z/17/Z
- Open Philanthropy Project
- Shurl and Kay Curci Foundation
- Weston Havens Foundation
- Caltech groups
- Division of Biology and Biological Engineering, Tianqiao and Chrissy Chen Institute for Neuroscience