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Published December 2021 | public
Journal Article

Single cell biology—a Keystone Symposia report


Single cell biology has the potential to elucidate many critical biological processes and diseases, from development and regeneration to cancer. Single cell analyses are uncovering the molecular diversity of cells, revealing a clearer picture of the variation among and between different cell types. New techniques are beginning to unravel how differences in cell state—transcriptional, epigenetic, and other characteristics—can lead to different cell fates among genetically identical cells, which underlies complex processes such as embryonic development, drug resistance, response to injury, and cellular reprogramming. Single cell technologies also pose significant challenges relating to processing and analyzing vast amounts of data collected. To realize the potential of single cell technologies, new computational approaches are needed. On March 17–19, 2021, experts in single cell biology met virtually for the Keystone eSymposium "Single Cell Biology" to discuss advances both in single cell applications and technologies.

Additional Information

© 2021 New York Academy of Sciences. Issue Online: 20 December 2021; Version of Record online: 03 October 2021; Manuscript accepted: 24 August 2021; Manuscript received: 24 August 2021. M.S. Balzer is supported by German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) Grant BA 6205/2-1. M. Ratz is supported by a DFG Research Fellowship, Grant RA 2889/1-1. J. Fan is supported by the National Science Foundation, Grant No. 2047611. The authors declare no competing interests.

Additional details

August 22, 2023
December 22, 2023