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Published July 1, 2021 | Published
Journal Article Open

Photoacoustic computed tomography for functional human brain imaging [Invited]


The successes of magnetic resonance imaging and modern optical imaging of human brain function have stimulated the development of complementary modalities that offer molecular specificity, fine spatiotemporal resolution, and sufficient penetration simultaneously. By virtue of its rich optical contrast, acoustic resolution, and imaging depth far beyond the optical transport mean free path (∼1 mm in biological tissues), photoacoustic computed tomography (PACT) offers a promising complementary modality. In this article, PACT for functional human brain imaging is reviewed in its hardware, reconstruction algorithms, in vivo demonstration, and potential roadmap.

Additional Information

© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Received 5 Mar 2021; revised 5 Jun 2021; accepted 8 Jun 2021; published 15 Jun 2021. The authors would like to thank David C. Garrett, Yilin Luo, and Olick G. Joshua for discussing and proofreading the manuscript. This work was sponsored by the United States National Institutes of Health (NIH) grants R01 NS102213 and U01 EB029823. Disclosures: L.V.W. has a financial interest in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which, however, did not support this work. S.N declares no competing interests.

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August 20, 2023
October 23, 2023